At Methodex we develop in vitro assays. Our specialists have extensive experience in conducting in vitro tests
- Genotoxicity tests:
- AMES test (OECD 471).
- Micronuclide assay (MNT) (OECD 487).
- Comet assay (ASTM E2 186-02A).
- Genetic mutation in mammalian cells (MLA) (OECD 476).
- Assajos of experimental toxicology in vitro:
- In vitro dermal corrosion test (RHE) (OECD 431).
- Skin irritation test (OECD 435) (Skinethic RHE).
- Phototoxicity assay in Balb / C or 3T3 cells (OECD 432) or with RHE.
- Local lymphatic nodule test (OECD 429).
- Sensitization test in human THP-1 cells (CD86 / CD54) (ECVAM).
- Dermal absorption in reconstituted human skin or pig skin (OECD 428).
- EpiOcular (test of ocular irritation in vitro, SIRC-NRU) or HET-CAM (ECVAM).
- Systematic cytotoxicity assay (keratinocytes, fibroblasts, B16, ...).
- MTT (INVITTOX 17).
- Neutral network (INVITTOX 64).
- Cell Transformation Assay in 3T3 A31.1-1 (CTA) (ENV / JM / MONO (2016) 1).
- Hemolysis test by surfactants (RBC) (INVITTOX 37).